Hydroxyacetophenone
What hydroxyacetophenone does as a cosmetic antioxidant and preservative booster, and why water-based products need preservation.
Extremely safeIn 60 products we cover
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Quick facts
- INCI name
- Hydroxyacetophenone
- CAS number
- 99-93-4
- Origin
- Synthetic
- Chemical class
- Aromatic ketone (phenolic compound)
- What it does in a formula
- antioxidant, preservative booster, skin conditioning
- Why it is in the formula
- Often added to help protect the formula from oxidation and support its preservation system.
What it is
In contemporary skincare formulations, hydroxyacetophenone functions as a dual-action antioxidant and preservative booster that supports product stability while soothing the skin. This aromatic compound frequently partners with primary preservatives in moisturizers and serums. It is not an exfoliating chemical or standalone active that demands dedicated routine adjustments.
Preservatives matter because many cosmetics contain water. Water-based products can support microbial growth unless the formula is designed to control it. A suitable preservation system helps protect the product during ordinary storage and use, along with appropriate packaging and handling. Hydroxyacetophenone may support that system, but its presence alone does not tell you which microbes a formula controls or how long a product will last after opening.
What it does
- Acts as an antioxidant. It can help protect formula components from oxidation.
- Supports preservation. It can boost a preservation system that helps limit unwanted microbial growth in a product.
- Conditions the formula. It may contribute to a comfortable skin feel in some products.
- Plays a supporting role. It is not a reason to buy a product on its own.
Who it suits
Most shoppers will encounter hydroxyacetophenone as one of several behind-the-scenes ingredients in a formula. It does not tell you whether the product is moisturizing, fragrance-free, or suitable for a particular concern. Check the whole ingredient list and choose the product texture and format you prefer.
Any cosmetic ingredient can bother some people, and a reaction may relate to another part of the formula. If a new product causes persistent discomfort, stop using it and reassess rather than assuming hydroxyacetophenone is the cause. If you have a known sensitivity or recurring reaction, a dermatologist can help identify what to avoid.
What to pair it with, and what not to
Hydroxyacetophenone does not need to be paired with a serum or active. It can be included with other preservatives such as phenoxyethanol or parabens as part of a formula’s preservation approach. Follow the package’s storage directions and do not use a product that has changed noticeably in smell, color, or texture.
Skin Realist check: Preservation is not an optional plot twist in a water-based product. It is part of the design.
Quick picks with Hydroxyacetophenone
Scent-free, no patch-test flags on the label
Sunday Riley A.I. Smart Retinoid Serum
Hydroxypinacolone Retinoate · scent-free label
AmazonBrand lists it for sensitive skin
Dermalogica dynamic skin retinol serum
Retinoid Complex 3.5% · oily, dry, combination, sensitive, normal skin · scented
AmazonBrand lists it for oily skin
Dermalogica awaken peptide depuffing eye gel
Caffeine, tetrapeptides, rosemary leaf extract, succinic acid blend, Voandzeia subterranea seed extract and lactic acid · oily, dry, combination, sensitive, normal skin · scent-free label
Amazon
All 60 products with Hydroxyacetophenone
Eye Creams & Under-Eye Patches (11)
COSRX Advanced Snail Hydrogel Eye PatchAmazon
Dermalogica awaken peptide depuffing eye gelAmazon
Laneige Bouncy & Firm Hydrogel Eye PatchesAmazon
Elemis Pro-Collagen Vitality Eye CreamAmazon
Dermalogica phyto nature lifting eye creamAmazon
COSRX 5 PDRN Collagen Vitalizing Hydrogel Eye PatchAmazon
Perricone MD High Potency Triple Retinol Renewal Eye SerumAmazon
Elemis Pro-Collagen Advanced Eye TreatmentAmazon
Elemis Pro-Collagen Eye Revive MaskAmazon
Elemis Pro-Collagen Future Restore Eye SerumAmazon
COSRX The Peptide Collagen Hydrogel Eye PatchAmazon
Hydrating Serums, Essences & Ampoules (7)
Dermalogica Smart Response SerumAmazon
Dermalogica stabilizing repair face + body serumAmazon
Dermalogica circular hydration serum with hyaluronic acidAmazon
Perricone MD High Potency Hyaluronic Intensive Hydrating SerumAmazon
Perricone MD High Potency Intensive Smoothing SerumAmazon
Elemis Pro-Collagen Renewal SerumAmazon
Elemis ULTRA SMART Pro-Collagen Complex SerumAmazon
Daily Moisturizers & Water Gel Creams (6)
Body Creams, Butters & Body Oils (5)
Anti-Aging & Retinoid Serums (4)
Gel, Foam & Cream Facial Cleansers (4)
Pimple Patches & Overnight Spot Treatments (3)
Mineral Pressed Powders & Skin-Nourishing Primers (3)
Dermatological Acne & Chemical Exfoliating Liquids (3)
Daily Sunscreens & SPF Moisturizers (2)
Targeted Vitamin C & Brightening Correctors (2)
Sheet, Hydrogel & Clay Masks (2)
Premium Double-Cleansing Balms & Melting Gels (2)
Skin Barrier Repair Creams & Recovery Jars (1)
Premium Overnight Recovery Packs & Sleeping Facials (1)
Physical & Enzyme Face Exfoliants (1)
Cream & Gel Treatment Masks (1)
Hydrating Toners, Essence Waters & Face Mists (1)
Eye Shadows, Liners, Mascara & Brow Makeup (1)
Common questions
What is hydroxyacetophenone in skincare?
Hydroxyacetophenone is an antioxidant and preservative booster used in cosmetics. It may also be included for skin-conditioning properties.
Is hydroxyacetophenone a preservative?
It is commonly used to support a product's preservation system, rather than being the only preservative. The finished formula may combine several ingredients to control microbial growth.
Why do moisturizers need preservatives?
Water-containing formulas can support the growth of bacteria, yeast, or mold if they are not adequately preserved. A preservation system helps maintain product quality during normal use.
Can I use hydroxyacetophenone with other skincare ingredients?
It is a supporting formula ingredient and does not need a special routine pairing. Choose products based on their full ingredient list and directions.

