High Potency Hyaluronic Intensive Hydrating Serum

What it is

Perricone MD describes this as a facial hydrating serum built around its Hyaluronic 4 + 2 Complex. The manufacturer also highlights DMAE and niacinamide.

Key ingredients

• Hyaluronic acid complex: The brand says its complex combines four forms and two natural building blocks of hyaluronic acid to support moisture retention and a smoother, plumper-looking complexion.
• DMAE: Perricone MD says it helps the skin look firmer and plumper over time.
• Niacinamide: The brand says this vitamin B3 ingredient supports the moisture barrier and helps improve the look of uneven tone and dullness.

What the brand claims

Perricone MD reports that 97% of participants in a clinical study of 35 women showed improved skin hydration for 72 hours. This is a manufacturer-reported result, not an independent assessment by us.

A facial hydrating serum with niacinamide, squalane and hyaluronic acid ingredients.

Manufacturer ingredient information

Manufacturer ingredient list

Water/Aqua/Eau, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, HDI/Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl MEA, Hydroxyacetophenone, Citric Acid, Ceramide NP, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate

Verified ingredient flags: None of the tracked ingredients identified in this published list.

Source: https://www.perriconemd.com/p/high-potency-hyaluronic-intensive-hydrating-serum/13156918/ (checked 2026-10-11).

Check the current package ingredient list before use; manufacturer formulas may change. Ingredient flags are presence checks, not safety judgments.

Sources

• https://www.perriconemd.com/p/high-potency-hyaluronic-intensive-hydrating-serum/13156918/ (checked 2026-10-11)
• https://www.perriconemd.com/p/high-potency-hyaluronic-intensive-hydrating-serum/13505362/ (checked 2026-10-11)

We have not tested this product.