Perricone MD
High Potency Intensive Smoothing Serum
A niacinamide serum with squalane, ceramides and multiple forms of hyaluronic acid.
- Fragrance free
What it is
Perricone MD names this product a High Potency Intensive Smoothing Serum. The formula is built around niacinamide, squalane, ceramide NP and several hyaluronic-acid forms, making it a comfort- and texture-focused serum in the brand’s daily skincare lineup.
Key ingredients
- Niacinamide: A multifunctional skin-supportive ingredient that may help smooth the look of uneven texture and support a balanced complexion.
- Acetyl glucosamine: A skin-conditioning ingredient that complements niacinamide in the formula.
- Squalane: A lightweight emollient that helps support softness and cushion without a heavy feel.
- Ceramide NP: A barrier-supportive ingredient that helps maintain the skin’s moisture retention.
- Sodium hyaluronate and hyaluronic acid: Multiple forms of hyaluronic acid help support hydration across the skin surface.
- Acetyl tetrapeptides: Peptides included to help support a smooth, firmer-looking appearance over time.
How to use
The official product page presents this as a smoothing serum in Perricone MD’s High Potency range. The brand does not provide a longer step-by-step routine on the product page, so the verified usage is limited to its product category and ingredient profile.
Who should be careful
The published formula does not list fragrance, but it does include multiple active and conditioning ingredients plus a few silicone-based film-formers. Anyone with skin sensitivities to niacinamide, hyaluronic-acid serums or silicone ingredients should patch test first. This is general information, not medical advice.
What the brand claims
Perricone MD positions this serum as a smoothing treatment in its High Potency collection. The product page highlights niacinamide, ceramides and hyaluronic-acid ingredients, but it does not include a detailed efficacy study or a separate claim page on the product listing itself.
Manufacturer ingredient information
Manufacturer ingredient list
Water/Aqua/Eau, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, HDI/Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl MEA, Hydroxyacetophenone, Citric Acid, Ceramide NP, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
Verified ingredient flags: None of the tracked ingredients identified in this published list.
Sources
- https://www.perriconemd.com/p/high-potency-intensive-smoothing-serum/14849701/ (checked 2026-10-11)
We have not tested this product.
What's on the label
| Category | Hydrating Serums, Essences & Ampoules |
|---|---|
| Brand | Perricone MD |
| Size | 2 fl. oz. |
| Form | Serum |
| Texture | Lightweight serum |
| Key ingredients | Niacinamide, acetyl glucosamine, squalane, ceramide NP, sodium hyaluronate, hyaluronic acid, acetyl tetrapeptides |
| Routine step | Serum |
| Free from | No fragrance is listed in the published ingredient list |
| Key ingredient | None stated |
| Best for | Not specified |
| Fragrance free | Yes |
| Worth knowing | Nothing flagged |
| Full ingredient list | Water/Aqua/Eau, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, HDI/Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl MEA, Hydroxyacetophenone, Citric Acid, Ceramide NP, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate |
| Size | Not stated |
| Source | Brand's own product page Checked |
Common questions
What is the main ingredient focus in this serum?
The published formula highlights niacinamide, acetyl glucosamine, squalane, ceramide NP and multiple forms of hyaluronic acid.
Does the brand list fragrance in the formula?
No fragrance ingredient appears in the published ingredient list.
What sort of product is this?
Perricone MD names it a High Potency Intensive Smoothing Serum in the brand's serum category.