Perricone MD

Cold Plasma Plus+ Fragile Skin Therapy

A body treatment with retinol, vitamin C derivative and micro-hyaluronic acid for thin, fragile-looking skin; Perricone directs use with moisturizer and SPF.

Published · Updated

  • Fragrance free

What it is

Perricone MD Cold Plasma Plus+ Fragile Skin Therapy is a body treatment for thin, fragile-looking skin. The brand describes it as helping improve the look of skin strength and smoothness on delicate areas.

Key ingredients

  • Growth Factor Peptide: Perricone describes this peptide complex as helping improve the appearance of skin tone and texture and reduce the look of thin, fragile skin.
  • Micro-Hyaluronic Acid: The brand says this smaller form of hyaluronic acid helps attract and deliver hydration.
  • Retinol: Retinol appears in the posted ingredient list; the page does not give its concentration.

How to use

Use morning and evening before moisturizer and SPF. Massage generously over the arms, shins or other areas with thin, fragile skin.

Who should be careful

The posted ingredient list includes retinol, and Perricone directs applying the treatment before SPF. Check the package ingredient list before use, especially if retinol is a concern. This is general product information, not medical advice.

What the brand claims

Perricone says the treatment promotes the look of stronger, more resilient skin, smooths the appearance of crepey or rough areas, and nourishes thin, delicate skin. These are manufacturer claims, not our findings.

Sources

A body cream formulated with glycerin and isopropyl myristate.

Manufacturer ingredient information

Manufacturer ingredient list

Water/Aqua/Eau, Glycerin, Isopropyl Myristate, Distearyldimonium Chloride, Stearyl Alcohol, Dimethicone, Cetyl Alcohol, 3-O-Ethyl Ascorbic Acid, Stearic Acid, Glyceryl Stearate, Tocopheryl Acetate, Sodium Metabisulfite, Ethylhexylglycerin, Retinol, Carnosine, Hydrolyzed Hyaluronic Acid, Xanthan Gum, Lecithin, Heptapeptide-7, Sodium Chloride, Sodium Hydroxide, Polysorbate 20, Propanediol, Phenoxyethano

Verified ingredient flags: Isopropyl Myristate

Source: https://www.perriconemd.com/p/cold-plasma-plus-plus-fragile-skin-therapy/12706432/ (checked 2026-10-11).

Check the current package ingredient list before use; manufacturer formulas may change. Ingredient flags are presence checks, not safety judgments.

We have not tested this product.

What's on the label

CategoryBody Creams, Butters & Body Oils
BrandPerricone MD
FormBody treatment
Key ingredientsGrowth Factor Peptide and Micro-Hyaluronic Acid; the ingredient list also includes retinol
Routine stepBefore moisturizer and SPF
When to useMorning and evening
Key ingredientNone stated
Best forNot specified
Fragrance freeYes
Worth knowingIsopropyl Myristate
Full ingredient listWater/Aqua/Eau, Glycerin, Isopropyl Myristate, Distearyldimonium Chloride, Stearyl Alcohol, Dimethicone, Cetyl Alcohol, 3-O-Ethyl Ascorbic Acid, Stearic Acid, Glyceryl Stearate, Tocopheryl Acetate, Sodium Metabisulfite, Ethylhexylglycerin, Retinol, Carnosine, Hydrolyzed Hyaluronic Acid, Xanthan Gum, Lecithin, Heptapeptide-7, Sodium Chloride, Sodium Hydroxide, Polysorbate 20, Propanediol, Phenoxyethano
SizeNot stated
SourceBrand's own product page
Checked

Common questions

Where should I apply Fragile Skin Therapy?

Perricone directs massaging it onto the arms, shins or anywhere with thin, fragile skin.

When should I use it?

The brand directs use in the morning and evening, before moisturizer and SPF.

Does the ingredient list include retinol?

Yes. Retinol appears in the manufacturer's posted ingredient list. The brand advises checking the current package list because formulas may change.