Perricone MD
Cold Plasma Plus+ Fragile Skin Therapy
A body treatment with retinol, vitamin C derivative and micro-hyaluronic acid for thin, fragile-looking skin; Perricone directs use with moisturizer and SPF.
- Fragrance free

What it is
Perricone MD Cold Plasma Plus+ Fragile Skin Therapy is a body treatment for thin, fragile-looking skin. The brand describes it as helping improve the look of skin strength and smoothness on delicate areas.
Key ingredients
- Growth Factor Peptide: Perricone describes this peptide complex as helping improve the appearance of skin tone and texture and reduce the look of thin, fragile skin.
- Micro-Hyaluronic Acid: The brand says this smaller form of hyaluronic acid helps attract and deliver hydration.
- Retinol: Retinol appears in the posted ingredient list; the page does not give its concentration.
How to use
Use morning and evening before moisturizer and SPF. Massage generously over the arms, shins or other areas with thin, fragile skin.
Who should be careful
The posted ingredient list includes retinol, and Perricone directs applying the treatment before SPF. Check the package ingredient list before use, especially if retinol is a concern. This is general product information, not medical advice.
What the brand claims
Perricone says the treatment promotes the look of stronger, more resilient skin, smooths the appearance of crepey or rough areas, and nourishes thin, delicate skin. These are manufacturer claims, not our findings.
Sources
- https://www.perriconemd.com/p/cold-plasma-plus-plus-fragile-skin-therapy/12706432/ (checked 2026-10-11)
A body cream formulated with glycerin and isopropyl myristate.
Manufacturer ingredient information
Manufacturer ingredient list
Water/Aqua/Eau, Glycerin, Isopropyl Myristate, Distearyldimonium Chloride, Stearyl Alcohol, Dimethicone, Cetyl Alcohol, 3-O-Ethyl Ascorbic Acid, Stearic Acid, Glyceryl Stearate, Tocopheryl Acetate, Sodium Metabisulfite, Ethylhexylglycerin, Retinol, Carnosine, Hydrolyzed Hyaluronic Acid, Xanthan Gum, Lecithin, Heptapeptide-7, Sodium Chloride, Sodium Hydroxide, Polysorbate 20, Propanediol, Phenoxyethano
Verified ingredient flags: Isopropyl Myristate
Source: https://www.perriconemd.com/p/cold-plasma-plus-plus-fragile-skin-therapy/12706432/ (checked 2026-10-11).
Check the current package ingredient list before use; manufacturer formulas may change. Ingredient flags are presence checks, not safety judgments.
We have not tested this product.
What's on the label
| Category | Body Creams, Butters & Body Oils |
|---|---|
| Brand | Perricone MD |
| Form | Body treatment |
| Key ingredients | Growth Factor Peptide and Micro-Hyaluronic Acid; the ingredient list also includes retinol |
| Routine step | Before moisturizer and SPF |
| When to use | Morning and evening |
| Key ingredient | None stated |
| Best for | Not specified |
| Fragrance free | Yes |
| Worth knowing | Isopropyl Myristate |
| Full ingredient list | Water/Aqua/Eau, Glycerin, Isopropyl Myristate, Distearyldimonium Chloride, Stearyl Alcohol, Dimethicone, Cetyl Alcohol, 3-O-Ethyl Ascorbic Acid, Stearic Acid, Glyceryl Stearate, Tocopheryl Acetate, Sodium Metabisulfite, Ethylhexylglycerin, Retinol, Carnosine, Hydrolyzed Hyaluronic Acid, Xanthan Gum, Lecithin, Heptapeptide-7, Sodium Chloride, Sodium Hydroxide, Polysorbate 20, Propanediol, Phenoxyethano |
| Size | Not stated |
| Source | Brand's own product page Checked |
Common questions
Where should I apply Fragile Skin Therapy?
Perricone directs massaging it onto the arms, shins or anywhere with thin, fragile skin.
When should I use it?
The brand directs use in the morning and evening, before moisturizer and SPF.
Does the ingredient list include retinol?
Yes. Retinol appears in the manufacturer's posted ingredient list. The brand advises checking the current package list because formulas may change.