Acne Relief Prebiotic Acne Therapy 30-Day Regimen

What it is

Perricone MD Acne Relief Prebiotic Acne Therapy is a three-product regimen with a cleanser, a daytime hydrator and a nighttime retinol moisturizer. The brand lists a 59 mL cleanser and two 21 mL treatments.

Key ingredients

• Sucrose and squalane: Listed in the Gentle & Soothing Cleanser; Perricone MD describes sucrose as a mild exfoliant and squalane as a lightweight hydrator.
• Citrulline, lactic acid and succinic acid: Listed in the Calming Treatment & Hydrator.
• Niacinamide and retinol: Listed in the Retinol Treatment & Moisturizer.

How to use

Perricone MD presents the cleanser as the first step, used morning and night; the Calming Treatment & Hydrator is the daytime treatment and the Retinol Treatment & Moisturizer follows cleansing at night.

Who should be careful

The two treatment formulas list SD Alcohol 40-B; the night treatment also lists retinol. The ingredient lists are not a medical assessment. This is general product information, not medical advice.

What the brand claims

Perricone MD describes the regimen as acne-focused care and highlights sucrose, citrulline, lactic and succinic acids, niacinamide, squalane and retinol. The page’s ingredient discussion also refers to salicylic acid, but that ingredient does not appear in any of the three component ingredient panels shown on the same page; we do not attribute it to the set formula.

Verified set contents

• Gentle & Soothing Cleanser: 59 mL.
• Calming Treatment & Hydrator: 21 mL.
• Retinol Treatment & Moisturizer: 21 mL.

Component formulas are recorded separately. No total set volume or combined ingredient formula is assigned.

Manufacturer ingredient information

Acne Relief Gentle & Soothing Cleanser

Glycerin, Sodium Cocoyl Isethionate, Ethylhexyl Palmitate, Silica Cetyl Silylate, Sucrose, Squalane, Polyacrylamide, Water/ Aqua/Eau, Caprylyl Glycol, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol

Verified ingredient flags: None of the tracked ingredients identified in this published list.

Source: https://www.perriconemd.com/p/prebiotic-acne-therapy-30-day-regimen/12639225/ (checked 2026-10-11).

Acne Relief Calming Treatment & Hydrator

Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, C12-15 Alkyl Lactate, PVP, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic Acid, Succinic Acid, Polyacrylamide, Dimethicone/Vinyl Dimethicone Crosspolymer, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Verified ingredient flags: Alcohol Denat.

Source: https://www.perriconemd.com/p/prebiotic-acne-therapy-30-day-regimen/12639225/ (checked 2026-10-11).

Acne Relief Retinol Treatment & Moisturizer

Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, Dicaprylyl Ether, Niacinamide, Citrulline, Arginine, Methyl Gluceth-20, Cetearyl Alcohol, Carbomer, Xanthan Gum, Tocopheryl Acetate, Retinol, Citric Acid, Sodium Hydroxide, Disodium EDTA, PEG-20 Methyl Glucose Sesquistearate, PEG-100 Stearate, Glyceryl Stearate, Methyl Glucose Sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Verified ingredient flags: Alcohol Denat.

Source: https://www.perriconemd.com/p/prebiotic-acne-therapy-30-day-regimen/12639225/ (checked 2026-10-11).

Check the current package ingredient list before use; manufacturer formulas may change. Ingredient flags are presence checks, not safety judgments.

Sources

• https://www.perriconemd.com/p/prebiotic-acne-therapy-30-day-regimen/12639225/ (checked 2026-10-11)

We have not tested this product.